To evaluate the binding of various hemagglutinins(PHAs) on the normal gastric mucosa, the author had been performed an experiment using Concanavalin A(Con-A), soybean agglutinin (SBA), wheat germ agglutinin (WGA), Dolichos biflorus agglutinin (DBA), Ulex europaeus agglutinin I(UEA I), peanut agglutinin (PNA), Ricinus communis agglutinin I (RCA I) and Pinellia ternata agglutinin (PTA). Every 5 cases of gastric mucosa from body, antral and pyloric portions were obtained by gastrectomy or endoscopic biopsy. The immunohistochemical method used was avidin-biotin system.
The results obtained are as follows;
1. To the foveolar epithelia of gastric mucosae, PNA, SBA, RCA I, and UEA I revealed positive reaction.
2. On the mucous neck cells, WGA and DBA showed positive intracytoplasmic reactions.
3. On the gastric glands of the body portion, Con-A, RCA I, UEA I, DBA and PTA showed
positive reaction. Con-A, WGA, PNA, RCA I, and UEA I revealed positive reaction on
the gastric glands of antral portion.
4. On the glands of intestinal ization, Con-A, WGA, RCA I, UEA I, DBA and PTA showed positive reactions.
With the above results, epithelial cells of the gastric mucosa showed various chemical compositions in their cytoplasmic membranes.
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